Chapter 31

Dermis layer of skin beneath the epidermis, which provides structural support to the skin and is composed of blood vessels, nerves, and appendages	Epidermis the outermost layer of the skin composed of five layers	Hypodermis third layer of skin composed of adipose (fat) tissue
Integumentary system the skin and its appendages (hair, glands, nails)	Local drug effect at site of application	Melanocytes cell located in the epidermis responsible for skin color
Stratum corneum outermost layer of the epidermis composed of nonliving keratinocytes	Topical applied to a surface of the body, such as the skin	Transdermal drug transport across or through the skin into the bloodstream